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There are many answers to this and we will try and cover at least some of them. So, what exactly are these medications that were discovered unintentionally and also have been used worldwide as a cure for certain ailments? Doctors have used BH4 and diets that exclude phenylalanine for almost a decade to treat PKU, a so-called inborn error of metabolism that if left untreated causes irreversible brain damage. In PKU, this enzyme coworker helps break down the molecule phenylalanine whose buildup is toxic to the brain. Researchers say this is the only form of the enzyme that functions normally, making more nitric oxide rather than free radicals. Add-on drugs include vitamin C or folic acid, both of which are known to interact with the so-called enzyme cofactor, and researchers plan to monitor closely for the effects of combined therapy on heart function, size and weight. The high-tech imaging allowed investigators to see microscopic injury to the cones of the retina, the cells which are responsible for color vision. OCT is an advanced imaging system that reveals the cross-sectional details of the retina layer by layer. Mount Sinai researchers used state-of-the-art technology, including adaptive optics (AO) and optimal coherence tomography (OCT), to examine his retina for evidence of structural damage at the cellular level, something that had never been done before. Richard Rosen, MD, Director of Retina Services at New York Eye and Ear Infirmary of Mount Sinai (NYEE). In a first-of-its-kind study, Mount Sinai researchers have shown that color vision problems caused by retinal damage on a cellular level can result from a high dose of sildenafil citrate, the popular erectile-dysfunction medication sold under the brand name Viagra. Protein kinase G is also the target of drugs like sildenafil (commonly known as Viagra). 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